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Orlistat for obesity benefits beyond weight loss. In conclusion, most large trials have found that statins or the combination of simvastatin with pravastatin significantly reduce mortality (5-10%) and cardiovascular events (including myocardial infarction, stroke and coronary artery disease), with no overall benefit for CVD events after 12 years in the absence of cardiovascular disease (5,10,30-32). These findings support the benefits of statins in prevention and control of CVD the benefits statins in reducing risk of type 2 diabetes, even for patients with elevated LDL cholesterol levels and high of LDL, HDL triglycerides (7). It is also possible that the benefits of statins for CVD are related to the lower cholesterol levels that occur after statin therapy, which suggests that there is no threshold or optimal LDL cholesterol level to achieve the benefits of statins for CVD, regardless the level of total cholesterol. In an attempt to improve the efficiency of this review and reduce the risk of bias, an independent consultant reviewed the original article and approved final manuscript; no conflicts were identified. REFERENCES 1. WHO. A summary of the evidence on effects statins cardiovascular disease from reviews involving more than 1 million participants in more than 60 000 randomised trials in > 30000 populations worldwide.. World Health Organ Tech Rep Ser 2009; 1551.. A summary of the evidence on effects statins cardiovascular disease from reviews involving more than 1 million participants in more than 60 000 randomised trials in > 30000 populations worldwide.. 2. J Intern Med 2001; 245 : 14 – 20. 3. Boffetta P Feskens EJ Virtamo J, et al. The effects of a combined simvastatin + pravastatin dose for up to 8 years on cardiovascular events and total mortality in patients with newly diagnosed and untreated hypercholesterolaemia: results from the European Multicentre Randomized Controlled Trials (EURES) study. Lancet 1998; 352 : 1819 – 25. 4. JAMA 2005; 294 : 1081 – 9. 5. Whelton PK Gannon MC Huggins CE, et al. The effects of a low-carbohydrate diet and statin on serum lipids cardiovascular risk factors: results of a randomized controlled trial in individuals with severe hyperlipidemia. Ann Intern Med 2005; 142 : 14 – 20. 6. Haddad EK Purnell JT The effect of lipid-lowering and antihyperlipidemic drugs Zithromax australia online metoprolol atorvastatin on coronary atherosclerosis in hypercholesterolaemic subjects. Arch Intern Med 1995; 155 : 1533 – 8. 7. D'Agostino RB Rosner B Viscoli P, et al. Effects of long-term treatment with pravastatin on coronary heart disease (CHD) risk factors in adults with elevated triglycerides. N Engl J Med 2001; 345 : 1717 – 25. 8. Purnell JT Gannon MC Jr Jr, et al. Effects of the statin simvastatin on incidence and progression of coronary artery disease in men with hypercholesterolaemia. JAMA 1998; 280 : 617 – 23. 9. Bessard T De Boer M Buitelaar H Geleijnse JM Staehelin HB Steegers-Theunissen RP Determinants of mortality in secondary prevention: results of the DARTEL trial. Arch Intern Med 1998; 158 : 2249 – 58. 10. Cappuccio FP Velloso G Pagni M, et al. The effect of a high-dose statin on coronary events in patients with newly diagnosed myocardial infarction: the PISSILE trial. Lancet 2000; 356 : 1499 – 504. 11. Tzoulaki S Pangalos C Papagiannakoulou A, et al. Long-term effects of lipid lowering and antihypertensive treatment on the risk of coronary heart disease in patients with acute coronary syndrome. Am Heart J 2010; 160 : 447 – 54. 12. Haddad EK Gannon MC Purnell JT Cholesterol-lowering and antihypertensive treatment the risk of stroke in women with acute coronary syndrome: the PROSPER purchase orlistat uk study. Am Heart J 1994; 119 : 973 – 7. 13. Purnell JT Gannon MC Jr Jr, et al. The effect of lipid lowering and antihypertensive treatment on the risk of stroke in women with acute coronary syndrome: results from the Women's Intervention Cardiovascular Risk in Women (WIC) trial. Am Heart J 2002; 145 : 535 – 41. 14. Nuts: health benefits and risks. BMJ 2007; 337 : b5886. 15.

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